Employing the thiol-ene click reaction via metal-organic frameworks for integrated sonodynamic-starvation therapy as an oncology treatment

Hypoxia in the tumor microenvironment (TME) greatly limits tumor-killing therapeutic efficacy of sonodynamic therapy (SDT); this phenomenon is further exacerbated by increased glutathione (GSH) levels cancer cells. Simultaneously, starvation increasingly recognized nowadays as a promising clinical translation, but glucose oxidase (GOx)-based also limited lack oxygen tumor. Glycer-aldehyde-3-phosphate dehydrogenase (GAPDH) key glycolytic enzyme and can therefore be target for absence engagement. Here, we proposed thiol-ene click reactions based on two-dimensional metal-organic framework (MOF) modification treatments to enable combination SDT therapy. Experimental studies demonstrated that prepared material could consume GSH GAPDH free from TME, which benefited between MOFs thiol substances Further experiments vitro vivo indicated MOF materials kill cells efficiently. This study expected create avenue cancer.